The Ocular Surface Disease Lab

Grace Orallo, a dual-degree student pursuing both her OD (Class of 2028) and a master’s degree, is conducting a thesis project that investigates how defined environmental stressors impact the ocular surface. Her research involves validating a novel Dye Eye Chamber capable of independently modulating temperature, humidity, and airflow in a controlled, reproducible manner. Utilizing in vivo tear collection, immunohistochemistry, and confocal imaging, she assesses alterations in tear composition, corneal epithelial integrity, and immune cell responses. The goal of her work is to inform clinical strategies for preventing and managing environmentally triggered dry eye.

Valaree Villegas, a dual-degree student pursuing both her OD (Class of 2027) and a master’s degree, has been instrumental in our project by conducting a retrospective data analysis of the Standard Patient Evaluation of Eye Dryness (SPEED) survey. Her work focuses on critically examining the limitations and predictive utility of the SPEED questionnaire in assessing the prevalence and severity of Dry Eye Disease.

Xin Yi Li, OD `26 Candidate
Xin Yi Li has contributed to our project that investigates the cellular signaling mechanisms triggered by neuroreceptors in the cornea and conjunctiva, specifically focusing on Substance P and Calcitonin Gene-Related Peptide. This research utilizes Type 2 Diabetes Mellitus (DM) mouse models under varying conditions, including desiccation stress and contact lens wear. Additionally, Xin Yi Li’s work delves into understanding how these neuroreceptor-mediated changes affect the ocular cytoskeleton and tight junction integrity, as well as influence the ocular surface’s microbial environment in Type 2 DM models.

Nahomy Nelson, an OD Candidate for 2027, has made significant contributions to our project focused on cellular signaling mechanisms in human conjunctival neuroreceptors. This research particularly emphasizes the roles of Substance P and Vasoactive Intestinal Peptide. Utilizing in vitro cell cultures, her work involves studying human conjunctival goblet cells derived from cadaver tissues of both diabetic and non-diabetic individuals. This approach provides valuable insights into the differential responses of these cells under diabetic conditions compared to normal states.

Sarah Krull, an OD + Master’s Candidate for 2027, plays a crucial role in our team as the animal facility manager and caretaker. Her expert management of the facility and attentive care for the animals are essential to maintaining the high standards of our research endeavors.

Valerie Winyuwongse, an OD Candidate for 2027, plays a crucial role in our team as the animal facility manager and caretaker. Her expert management of the facility and attentive care for the animals are essential to maintaining the high standards of our research endeavors.