The Ocular Surface Disease Lab

Grace Orallo, a dual-degree student pursuing both her OD (Class of 2028) and a master’s degree, is conducting a thesis project that investigates how defined environmental stressors impact the ocular surface. Her research involves validating a novel Dye Eye Chamber capable of independently modulating temperature, humidity, and airflow in a controlled, reproducible manner. Utilizing in vivo tear collection, immunohistochemistry, and confocal imaging, she assesses alterations in tear composition, corneal epithelial integrity, and immune cell responses. The goal of her work is to inform clinical strategies for preventing and managing environmentally triggered dry eye.

Valaree Villegas, a dual-degree student pursuing both her OD (Class of 2027) and a master’s degree, has been instrumental in our project by conducting a retrospective data analysis of the Standard Patient Evaluation of Eye Dryness (SPEED) survey. Her work focuses on critically examining the limitations and predictive utility of the SPEED questionnaire in assessing the prevalence and severity of Dry Eye Disease.

Joseph Carew, OD Candidate 2029, has contributed to our project investigating diabetic corneal neuropathy and the clinical utility of ocular biomarkers. This research explores how metabolic dysregulation alters corneal nerve health and ocular surface integrity. Specifically, Joseph’s work focuses on identifying key biomarkers within the cornea and tear fluid that could serve as early, non-invasive diagnostic indicators for diabetes and the progression of other diabetes-associated systemic complications.

Zoe Liu, OD Candidate 2029, has contributed to our project evaluating novel therapeutic interventions to prevent diabetic corneal neuropathy and promote corneal nerve regeneration. Her research investigates the efficacy of localized treatments, including topical insulin drops, GLP-1 receptor agonists, and various neuropeptide agents. In addition to tracking nerve recovery, Zoe’s work explores how these treatments influence broader ocular surface parameters, such as epithelial integrity and wound healing. Furthermore, she is analyzing alterations in tear fluid composition to better understand the underlying metabolic and inflammatory shifts occurring on the diabetic ocular surface.

Serena Rawle, an OD Candidate for 2029, plays a crucial role in our team as the animal facility manager and caretaker. Her expert management of the facility and attentive care for the animals are essential to maintaining the high standards of our research endeavors.

Maya Szeto, an OD Candidate for 2029, plays a crucial role in our team as the animal facility manager and caretaker. Her expert management of the facility and attentive care for the animals are essential to maintaining the high standards of our research endeavors.

Valerie Winyuwongse, an OD Candidate for 2027, plays a crucial role in our team as the animal facility manager and caretaker. Her expert management of the facility and attentive care for the animals are essential to maintaining the high standards of our research endeavors.