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Sangeetha Metlapally, BS Opt, PhD, FAAO

Sangeetha Matlapally

Research Profile

PhD in Vision Science, The University of Melbourne, Australia

BS in Optometry, Birla Institute of Technology and Science (BITS), Pilani, India and Elite School of Optometry (ESO), Chennai, India

phone: 617-587-5774

Research Interests  

The focus of Dr. Metlapally’s research is the influence of the eye’s optical imperfections (aberrations) on our ability to combine images/scenes from the two eyes (binocular vision). There is a sizeable overlap in the scenes we view through each eye.

Normally, we integrate matched information from 2-D (dimensional) retinal images formed in each eye and use small differences between each eye’s view to discern depth information to perceive a clear and single image in 3-D. This represents the optimal high-level functioning state of our binocular vision. Optical aberrations affect the image quality of each eye, and therefore would impact binocular vision. Increased amounts of optical aberrations are seen in diseases such as keratoconus or pellucid marginal degeneration, and where they are introduced as an undesirable side-effect following corneal transplantation, or refractive surgery (e.g., LASIK). Current clinical management paradigms for these conditions do not address binocular or 3-D perception important for patients’ daily functioning and vision-related quality of life.

Specifically, we are exploring how increased and mismatched aberrations between the two eyes in the above conditions affect retinal image quality in each eye and binocular matching. In addition, we are investigating how magnification differences between the two eyes from conventional optical corrections might interfere to decrease stereo-depth (3-D) perception. The influence of optical aberrations on the young eye’s ability to bring near objects into focus (accommodation) has also been a subject of our recent studies. Our studies merge basic and clinical research, both in binocular vision and advanced optics to study these effects. Tools used in our research include, but are not limited to optical wavefront analyses to characterize the optics of the eye or optical corrections, psychophysical techniques to measure responses to visual stimuli, and computational modeling to analyze and predict the effects of optical imperfections on retinal image quality. We actively collaborate with researchers at UC Berkeley as well as LV Prasad Eye Institute (India), and welcome new collaborations in these and complementary areas. 

Understanding how aberrations impact vision could help us customize optical corrections and discover new clinical management strategies to improve the binocular visual quality in patients. It could also help create new clinical tools to predict the effects of uncorrected aberrations on binocular vision. 


Prof. Clifton M. Schor (University of California, Berkeley, USA)

Prof. Austin Roorda (University of California, Berkeley, USA)

Dr. Shrikant Bharadwaj (LV Prasad Eye Institute, India)

Professional memberships

  • Association for Research in Vision and Ophthalmology (ARVO) 
  • Fellow of the American Academy of Optometry (FAAO)


Please click here for a full list of Dr. Metlapally’s peer-reviewed journal publications.