On Tuesday, September 15, 2015, Dr. Francois Delori, of Schepens Eye Research Institute in Boston,MA will present “Probing RPE with Light” as part of the College’s Light InSight Lecture Series.
Abstract: Lipofuscin accumulates throughout life in the RPE as a byproduct of the visual cycle and is a complex mixture of bisretinoids (including A2E) and their oxidized forms. Mutations in photoreceptor genes can have a direct impact on RPE lipofuscin levels, such as is the case for ABCA4-related retinal disorders. Adverse effects of RPE lipofuscin has been demonstrated in-vitro including generation of free radicals and photooxidation-associated complement activation. We have developed different in-vivo methods to quantify the autofluorescence of lipofuscin. These techniques will aid in achieving a better understanding of the role of lipofuscin in disease pathogenesis, and could contribute to the assessment of drug and gene therapies.