The Choi-Doble Laboratory develops and implements adaptive optics (AO) technology for the study of the human visual system.
The eye provides the only direct view of the central nervous system and is, therefore, subject of intense interest as a means to the early detection of retinal and systemic diseases. However, high-order aberrations in the eye limit the optical quality of the human eye, reducing image contrast and resolution. AO can compensate for these ocular aberrations allowing visualization of retinal structures at the cellular level, e.g., cone and rod photoreceptors, retinal pigment epithelium cells, leukocyte blood cells and capillaries in living eyes without using contrast enhancing agents.
Our research goals are to use AO imaging and psychophysical techniques to enhance our understanding of disease mechanisms and also to detect onset of disease much earlier than has been possible through conventional clinical testing.